The Ultimate Fat Loss Supplement Stack

The Ultimate Fat Loss Supplement Stack

‘If only there was a magic pill or potion that’d help me melt this fat away…’

How many of you have had that thought running through your head at least once during a fat loss diet?

We’ve all been there.

It’s human behaviour in this modern-day world to chase the ‘secret formula’ with a hit of instant gratification. But the harsh reality is that to carry a decent amount of muscle tissue at a low level of body fat is hard work that offers no shortcut, and no magic pill!

That being said, what we can do is control as many variables as possible that we have in our arsenal, and use this to create our own ‘secret formula’. What this really consists of is nailing your diet, going hard in your training, getting your cardio done, staying active with your steps, and taking your supplements. All of this combined done with ruthless consistency every day can produce outstanding results over time.

Now, if you’re doing all of this without fail, there are a few ‘1% solutions’ that we’re a fan of using. The first combination we’ll discuss – caffeine and yohimbine HCL – are almost staples for anyone looking to get really lean and help get rid of the last few pounds of stubborn body fat. The latter two are used less often, but worth mentioning.

Note: The advice is in this article is for those of you with serious goals chasing aggressive fat loss, and wanting to take it to the next level. It’s for those looking to get very lean, and/or doing a photoshoot or a physique competition.

Caffeine & Yohimbine HCL – Why Do They Work?

1. Caffeine

We’ve all heard of caffeine. It’s a CNS (Central Nervous System) stimulant that’s responsible for the kick you get from your morning coffee. Although the research varies on the exact numbers, it may increase metabolism by 1-3%. Which certainly makes it worth trying.

It comes with a number of benefits, including:

– Allows you to work that extra bit harder than normal in your training and cardio sessions. This is especially true towards final stages of a dieting phase where energy levels are typically low and it can be tough to get your heart rate up during cardio.

– Decreases pain perception. If you take it pre weight training, or HIIT, it may allow you to push a little further out of your comfort zone.

– Releases cortisol to help mobilise fatty acids to be used as fuel more efficiently.

The benefits of caffeine make it an easy addition to any fat loss supplement stack, and it’s why it’s the key ingredient in ‘fat burners’ you’ll often find in supplement stores.

2. Yohimbine HCL

Yohimbine HCL is a little less known, and it’s important when buying it that you don’t confuse it with Yohimbine Bark. This can be tough to dose correctly, and often causes sickness or nausea.

This is also a stimulant, but where its value comes is its ability to ‘block’ alpha 2 receptors within fat cells.

Why is this important?

It appears that our ‘stubborn’ body fat areas are linked to sites rich in these alpha 2 receptors. If you look at the diagram below, you’ll see that these stubborn fat areas are typically in the lower back, lower pecs, abdomen, triceps, hips and thighs. You’ll also notice that the former three are typically more common for men, while the latter apply more to women (although not definitive).

These alpha 2 rich areas are known to have a poor blood supply, so even when we exercise, it’s hard to mobilise and ‘move’ these fatty acids. They also appear to ‘inhibit’ fat loss via signalling of HSL (Hormone Sensitive Lipase), which works as a key fat releasing enzyme in the body.

As an ‘alpha 2 adreno receptor antagonist’, yohimbine HCL can work by helping ‘switch off’ these alpha 2 receptors. In turn, we may be able to increase blood flow and switch on lipolysis (fat burning) in stubborn areas.

When Should You Take Your Caffeine & Yohimbine?

The best time to take this combination is in a fasted state before cardio. An ideal scenario would be to wake up, take your caffeine and yohimbine, wait 20 minutes for them to kick in, and then start your cardio.

When we wake up, cortisol (stress hormone) should be relatively high. So by taking caffeine, we’re able to amplify these effects to help mobilise more fatty acids to use as fuel. While cortisol has received a bad rap, if it’s high at certain times of the day, it can be very beneficial.

In regards to yohimbine, it’s best advised to be taken away from carbohydrate. High levels of insulin cancel its effectiveness, and what better time of day do we have naturally low levels of insulin? First thing in the morning!

How Much Should You Dose Your Caffeine & Yohimbine?

How you dose your caffeine to begin with will depend on your tolerance to stimulants. If you’re not used to taking any caffeine, you may want to start with a black coffee. Once accustomed to this (which contains approx. 50-100mg caffeine depending on strength), then we recommend buying some plain caffeine tablets (which usually start at 200mg). You can also monitor and adjust your dose much easier this way.

For women, we’d recommend starting with ½ a tablet and assessing your tolerance and side effects.

For men, we’d recommend starting at 1 tablet.

After starting with 100-200mg, you can ramp this up to 400-600mg over time depending on how your body reacts.

In Lyle McDonald’s excellent book, ‘Women and Fat Loss’, he noted that by taking 600mg caffeine per day can burn up to 100 calories a day extra. This isn’t a huge amount, but over time this can add up, and possible burn an extra pound of body fat in a month’s time. Of course, you shouldn’t suddenly start taking 600mg/day, and should certainly build up to such an amount over time.

For yohimbine HCL, the most effective dose is 0.2mg/kg.

So if you weigh 70kg, you’d be looking at taking approximately 14mg. Each capsule is typically 2.5mg, so this would equate to 5-6 capsules per day.

It’s important here to start at 1-2 capsules for a couple of days to assess tolerance, and then titrate up accordingly.

In the depths of extreme fat loss diets where you’re really pushing things, we may also add a second dose in during the afternoon. But remember, insulin inhibits yohimbine’s effectiveness, so try keep this away from carbohydrate-based meals, and/or 2 hours after eating.

What Are The Potential Side Effects?

How you respond to a specific supplement will depend on you, but as with all stimulants, the most common potential side effect if you’re not used to them is feeling ‘jittery’.

Stimulants can also amplify feelings of anxiousness, so if you’ve got a history of depression, anxiety or panic attacks, do not take them.

Potential positive side effects can include decreased appetite (useful towards the end of a diet) and increased well-being / libido.

There is some controversy as to the legality of Yohimbine HCL in the UK. It is a controlled substance in that a license is needed to sell it (hence we typically have to order it from the US), but it’s totally legal to use and not a banned substance in the majority of sport federations. Despite this, you should always do your own research and check with your federation (in either physique or athletic endeavours) as rules and regulations are constantly changing.

Bonus Supplement #1 –  MPA Supps Vasoburn

This is an interesting product which at first glance, you may be just as sceptical as we were when we first came across this. Anytime a topical formula that should only be applied to specific ‘stubborn’ areas comes out, it normally comes with a roll of the eyes.

But when the late Matt Porter, a highly innovative and knowledgeable physique coach, formulated this product, we knew there would be at least some merit to it.

So far so good, and for those looking for that extra 0.5% edge to tick another small box, this can be worth trying.

It contains a number of active ingredients, with one of the main ones being Yohimbine HCL.

The real question is though, how does it get through the skin and start work on those alpha-2 fat receptors? The answer lies in the inclusion of tetrahydropiperine, which has been shown to successfully penetrate the epidermis and dermis, and increasing absorption of nutrients through the skin.

What really makes Vasoburn unique is that it also contains theophylline. Many studies now show that when applied topically (in the abdominal and thigh region), it can induce localised fat loss.

When you combine the qualities of those three ingredients, you’ve got something pretty cool on your hands!

How Do You Use Vasoburn?

The best way to use it is to apply it to the areas which are stubborn for you. For men, this is likely lower abdominals and love handles. For women, it’s typically hips, thighs and sometimes triceps.

We’d recommend applying it before bed, after showering, and allowing it to soak in overnight. Once you’re up, you’d use the caffeine and yohimbine combination and do your cardio.

During the cardio, you’ll feel the tissues heating up and increasing in blood flow, which is a major component in fat loss. In fact, if you think about the most ‘stubborn’ areas in your body after a hard session, they’re typically cooler than other areas and suffering from a lack of blood flow.

Once you’ve done your cardio, we’d recommend applying it later in the day whenever you shower.

One quick tip when applying… always wash your hands thoroughly afterwards! Or wear gloves. You don’t want to be touching the wrong areas after applying Vasoburn!

This might all sound a little wacky, and it’s critical to understand that this will only provide the small edge that it gives if you’re doing everything else right, day in and day out.

Bonus Supplement #2 – ProjectAD Shredabull

This stuff is insane. The first time you try this, you’ll be off the charts.

As a word of warning, you only want to start with one capsule, first thing in the morning.

The first time you take this is one you’ll always remember! Expect to be flying through your cardio pouring in sweat like never before. It really is that strong.


The incredible energy, sustained mental focus and appetite suppressing benefits this brings is likely from the combination of caffeine and a relatively new stimulant, 2-aminoisoheptane (DMHA).

To add to this, AD have also added in a few compounds to help increase thermogenesis. The first two are typical of many ‘fat burners’, white willow bark and cayenne. However, it’s likely the addition of higenamine that gives this product it’s potent fat burning effect.

Higenamine appears to be a beta-2 agonist, which funnily enough works perfectly with our friend we spoke about earlier, yohimbine HCL, which works as an alpha-2 antagnoist.

Like we have alpha-2 receptors on our fat cells (the stubborn ones yohimbine HCL inhibit), we also have beta-2 adreno receptors, which work in the opposite way to alpha receptors and give up fatty acids easily!

An antagonist’s goal is to down regulate a receptor, whereas an agonist’s goal is to up-regulate a receptor. So theoretically, combining a product like Shredabull Untamed (which up-regulates the beta-receptors) with yohimbine HCL (which down-regulates alpha-receptors) creates the ideal fat loss combination.


It can become easy to think after reading an article like this that you’ve found the magic key to unlock your fat loss to the next level.

But remember, supplements are just that, supplements. It’s the extra 1% that could make a difference if all the basics are being nailed on a consistent basis. If not, you’ll end up spinning your wheels and wasting a lot of money!

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Akash Vaghela is the Founder of RNT Fitness, where his mission is to see a world where everyone experiences the power of a physical body transformation to act as a vehicle for the greater good in their lives. Akash has produced 200+ blogs, 100+ videos and hosts the RNT Fitness Radio podcast, which has amassed over 110,000 downloads in 90+ countries across 100+ episodes. Alongside this, he's been seen in Men's Health, BBC, T-Nation, Elite FTS and the PTDC, while also regularly speaking nationally and internationally on all things transformation.